Crosslinked Sodium Carboxymethyl Cellulose CCMCNa China Suppliers and Factory
Cross-linked sodium carboxymethyl cellulose (CCMC-Na) is a high-performance, chemically modified cellulose derivative engineered primarily for the pharmaceutical industry. Serving as a superior super-disintegrant for tablets and capsules, CCMC-Na utilizes a specialized cross-linked structure that enables rapid water absorption and swelling without dissolution. This mechanism significantly accelerates the disintegration of oral dosage forms, thereby optimizing the dissolution rate and enhancing the therapeutic efficacy of active pharmaceutical ingredients (APIs).
Available as a white or off-white fine powder or granular form, CCMC-Na is characterized by its exceptional flow properties, precise particle size distribution, and superior surface characteristics. These attributes ensure seamless mixing and filling operations during the pharmaceutical manufacturing process. Compliant with the Chinese Pharmacopoeia 2020 edition (Volume 4), it provides a stable, biocompatible, and non-toxic solution for formulators seeking to improve tablet hardness and reduce brittleness while ensuring consistent drug release.
Detailed Parameters
| Adhesion Index | 0.0456 | Brittleness Index | 0.1000 |
|---|---|---|---|
| Bulk Density | 0.529 g/cm³ | Angle of Repose | 44° |
| Specific Surface Area | 0.81-0.83 m²/g | pH Value | 5.0-7.0 |
| Degree of Substitution | 0.60-0.85 | Water Soluble Matter | ≤10.0% |
| Loss on Drying | ≤10.0% | Residue on Ignition | 14.0-28.0% |
Key Advantages
High Efficiency Disintegration
Rapidly absorbs water and swells without dissolving, significantly accelerating the disintegration of tablets and capsules.
Rapid Water Absorption
Strong capillary action allows the product to absorb large volumes of water in short timeframes, optimizing absorption rates.
Excellent Stability
Remains chemically stable across a wide range of pH values, preventing degradation in diverse drug formulations.
Superior Biocompatibility
Non-toxic and non-irritating, ensuring safety and compatibility with the human body as a pharmaceutical excipient.
API Compatibility
Does not interfere with the activity of active ingredients, ensuring the safety and potency of the final drug product.
Improved Physicality
Enhances tablet hardness, reduces fragility, and improves the overall smoothness and appearance of the preparation.
Product Gallery
Management Platforms
Wet Granulation
Can be added during wetting or drying stages; external addition typically yields superior disintegration results.
Direct Tableting
Optimized for direct compression processes with a recommended standard dosage of approximately 2.0% (W/W).
Dosage Control
Flexible dosing from 0.5% to 5.0% for tablets, and 10.0% to 25.0% for capsule disintegrants.
Quality Assurance
Strict adherence to the Chinese Pharmacopoeia 2020 standards for purity, substitution, and heavy metal limits.
Storage Protocol
Highly hygroscopic material; must be kept in sealed containers in cool, dry environments to maintain stability.
Packaging Standard
Supplied in paper-plastic composite woven bags with double-layer PE liners, net weight 25kg per bag.
Investment Return Comparison
| Performance Metric | Common Disintegrants | CCMC-Na (Super Disintegrant) |
|---|---|---|
| Swelling Capacity | Moderate | Extremely High |
| Disintegration Speed | Standard | Rapid/Accelerated |
| Tablet Hardness | Variable | Enhanced/Stable |
| API Compatibility | Moderate | High/Non-reactive |
| Dosage Efficiency | High Volume Required | Low Dosage (0.5% - 5%) |
Frequently Asked Questions
Q: What is the primary difference between CCMC-Na and standard CMC?
Unlike standard CMC which dissolves in water, CCMC-Na is cross-linked. This means it swells rapidly upon contact with water but does not dissolve, creating a powerful internal pressure that breaks the tablet apart faster.
Q: How should CCMC-Na be added during wet granulation?
It can be added during the wetting or drying stage. However, for maximum disintegration efficiency, adding it as an external disintegrant (outside the granules) is generally more effective.
Q: Are there any chemical incompatibilities with CCMC-Na?
Yes, CCMC-Na is incompatible with strong acids and soluble salts of iron or other metals such as aluminum, mercury, and zinc.
Q: What is the recommended dosage for direct tableting?
For direct tableting processes, the typical dosage is around 2.0% (W/W), although the range can be adjusted between 0.5% and 5.0% depending on the formulation.
Q: How does CCMC-Na affect tablet brittleness?
CCMC-Na is designed to enhance tablet hardness and reduce brittleness, ensuring that the preparation remains durable during handling and transport without sacrificing disintegration speed.
Q: Is CCMC-Na safe for human consumption in pharmaceuticals?
Yes, it is generally considered non-toxic and non-irritating. While it may have a laxative effect if taken in very large oral quantities, the typical amounts used in solid preparations are safe.
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