High Substituted Hydroxypropyl Cellulose China Suppliers and Factory
High Substituted Hydroxypropyl Cellulose (H-HPC) is a premium modified cellulose polymer synthesized by introducing hydroxypropyl groups into the natural cellulose molecular chain. Recognized for its exceptional water solubility and unique thermoplastic properties, H-HPC serves as a versatile additive across high-precision industries. It appears as a white or off-white powder capable of forming transparent to translucent viscous solutions, making it an essential component in pharmaceutical, food, and cosmetic formulations.
Engineered for stability and performance, H-HPC is non-ionic, chemically inert, and physiologically harmless. Its distinctive ability to undergo reversible gelation based on temperature changes, combined with its superior film-forming capacity and antibacterial properties, allows manufacturers to optimize product texture, stability, and drug release profiles. Whether used as a binder, stabilizer, or coating agent, H-HPC ensures high-quality results and consistent industrial performance.
Detailed Parameters
| Hydroxypropoxy (Wt%) | 53.4 - 80.5 | Loss on drying (Wt%) | ≤ 5.0 |
|---|---|---|---|
| pH Value | 5.0 - 8.0 | Ignition residue (Wt%) | ≤ 0.8 |
| Arsenic salts (ppm) | ≤ 2 | Heavy metals (ppm) | ≤ 10 |
| Chlorides (Wt%) | ≤ 0.15 | Silicon dioxide (Wt%) | ≤ 0.6 |
| Toluene (Wt%) | ≤ 0.089 | Isopropyl alcohol (Wt%) | ≤ 0.5 |
Key Advantages
Physiological Safety
H-HPC is non-toxic, chemically inert, and has no pharmacological effect, ensuring absolute safety for medical and food use.
Thermal Stability
Features a precise thermoplastic range of 130-150°C while retaining full water solubility after processing.
Superior Film-Forming
Produces tough, glossy, and elastic films with low equilibrium moisture, ideal for protective coatings.
Wide pH Stability
Non-ionic nature ensures it does not gel in acidic solutions and remains stable across a wide pH spectrum.
Antibacterial Properties
Uniform substituent distribution provides inherent antibacterial properties, enhancing product shelf-life.
Multi-Functional Utility
Possesses the unique ability to gel, emulsify, foam, suspend, and thicken in various solvent environments.
Product Gallery
Management Platforms
Pharma-Grade Binding
Optimized as a binder for tablets and granules (1%-5% dosage) to improve hardness and dissolution.
Advanced Film Coating
Used for high-elasticity tablet coatings, preventing moisture absorption and increasing stability.
Emulsion Stabilization
Acts as a high-performance thickener for solvents and stabilizer for cosmetic lotions.
Controlled Release
Serves as a skeleton material for sustained-release pellets and double-layer tablets.
Ointment Base Gel
Provides ideal viscosity and texture for ethanol-based gels and therapeutic ointment bases.
Local Drug Carrier
Forms high-tensile strength films in organic solvents for localized medical drug delivery.
Investment Return Comparison
| Feature Index | Standard Cellulose | High Substituted HPC |
|---|---|---|
| Water Solubility | Moderate/Variable | Excellent & Fast |
| Thermal Range | Limited | 130-150°C Thermoplastic |
| Film Toughness | Fragile/Low Gloss | High Toughness & Gloss |
| pH Compatibility | Narrow Range | Wide range/Non-ionic |
| Biological Safety | Basic Grade | Pharma-Grade/Non-Toxic |
Frequently Asked Questions
Q: What is the primary difference between H-HPC and standard cellulose?
H-HPC is highly modified with hydroxypropyl groups, providing superior thermoplasticity, better water solubility, and higher stability across various pH levels compared to standard cellulose.
Q: How should H-HPC be dissolved in water to avoid lumps?
Either slowly add H-HPC to vigorously stirred water, or heat 20-30% of the water to above 60°C before stirring in the powder, then adding the remaining water.
Q: Which H-HPC model is recommended for tablet binding?
For pharmaceutical binding in tablets and granules, the TZ-L or TZ-J models are generally selected to improve hardness and dissolution stability.
Q: Can H-HPC be dissolved in organic solvents?
Yes, it is soluble in several organic solvents including glacial acetic acid, acetone:water (9:1), chloroform, ethanol, and ethylene glycol.
Q: What are the storage requirements for H-HPC powder?
H-HPC is hygroscopic; it must be stored in sealed containers, kept away from direct sunlight and rain, and isolated from acids and alkalis.
Q: Is H-HPC compatible with the Chinese Pharmacopoeia?
Yes, our High Substituted Hydroxypropyl Cellulose complies with the 2020 edition of the Chinese Pharmacopoeia (Part 4).
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