High Substituted Hydroxypropyl Cellulose HHPC China Factory and Suppliers
High Substituted Hydroxypropyl Cellulose (H-HPC) is a premium modified cellulose ether engineered by introducing hydroxypropyl groups into the cellulose molecular chain. This advanced chemical structure grants the material exceptional water solubility and unique thermoplasticity, making it an indispensable additive across the pharmaceutical, food, and cosmetic sectors.
Appearing as a white to off-white powder, H-HPC is renowned for its superior film-forming properties and chemical inertness. It forms transparent to translucent viscous solutions that remain stable across a wide pH range, providing critical functionality as a binder, thickener, and stabilizer in high-performance industrial formulations.
Detailed Parameters
| Hydroxypropoxy (Wt%) | 53.4 - 80.5 | Loss on Drying (Wt%) | ≤ 5.0 |
|---|---|---|---|
| pH Value | 5.0 - 8.0 | Ignition Residue (Wt%) | ≤ 0.8 |
| Arsenic Salts (ppm) | ≤ 2 | Heavy Metals (ppm) | ≤ 10 |
| Chlorides (Wt%) | ≤ 0.15 | Silicon Dioxide (Wt%) | ≤ 0.6 |
| Toluene (Wt%) | ≤ 0.089 | Isopropyl Alcohol (Wt%) | ≤ 0.5 |
Key Advantages
Biocompatible & Safe
Non-toxic and physiologically harmless, H-HPC is chemically inert, ensuring safety in medical and pharmaceutical applications.
Thermal Stability
Excellent thermoplastic range (130-150°C) while maintaining water solubility after thermoplastic processing.
Superior Film-Forming
Produces tough, elastic films with high gloss, ideal for tablet coatings and drug carrier membranes.
pH Versatility
Non-ionic nature ensures stability across a wide pH range without gelation in acidic solutions.
Anti-Bacterial Effect
Uniform substituent distribution provides intrinsic antibacterial properties for enhanced product shelf-life.
Low Ash Content
Extremely low residue ensures excellent adhesion and stability as an emulsion adhesive.
Product Gallery
Management Platforms
Grade Selection
Customized viscosity grades from TZ-G to TZ-H to meet specific binding and thickening needs.
Precision Synthesis
Controlled etherification process ensuring uniform distribution of hydroxypropyl groups.
Quality Assurance
Strict compliance with the 2020 Chinese Pharmacopoeia (Part 4) standards.
Solubility Control
Optimized dissolution methods for both aqueous and organic solvent systems.
Secure Packaging
Moisture-proof PE-lined cardboard barrels (25kg) to preserve chemical integrity.
Application Support
Expert guidance on dosage (1%-5%) for tablets, granules, and ointment gels.
Investment Return Comparison
| Application Type | Standard Cellulose | H-HPC Advantage |
|---|---|---|
| Tablet Binding | Standard Hardness | Improved Hardness & Stability |
| Film Coating | Brittle Texture | High Toughness & Elasticity |
| Sustained Release | Linear Release | Controlled Skeleton Matrix |
| Emulsion Stability | pH Sensitive | Wide pH Range Stability |
| Solvent Thickening | Limited Solvents | Multi-Solvent Compatibility |
Frequently Asked Questions
Q: What is the main difference between H-HPC and standard HPC?
H-HPC features a higher degree of hydroxypropyl substitution, which significantly enhances its thermoplasticity and stability across varying pH levels compared to standard cellulose ethers.
Q: How should H-HPC be dissolved in water to avoid lumps?
Slowly add H-HPC to vigorously stirred water. Alternatively, heat 20-30% of the water to above 60°C, add the powder under stirring, and then add the remaining water.
Q: Which H-HPC grade is recommended for tablet binding?
For use as a binder in tablets and granules, TZ-L or TZ-J grades are generally recommended, typically at a dosage of 1%-5% of the drug weight.
Q: Is H-HPC compatible with organic solvents?
Yes, H-HPC is soluble in various organic solvents including glacial acetic acid, acetone/water mixtures, ethanol, and dichloromethane/methanol mixtures.
Q: What are the storage requirements for this product?
H-HPC is hygroscopic and must be kept in sealed containers. Store in a cool, dry area away from direct sunlight, rain, and contact with strong acids or alkalis.
Q: Can H-HPC be used for sustained-release drug delivery?
Yes, it serves as an excellent skeleton material for sustained-release tablets and pellets, with the TZ-M grade being the preferred choice for these applications.
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