Premium HPMCAS Suppliers in China | HighQuality Pharmaceutical Factory
Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS) is a high-performance semi-synthetic polymer derived from natural cellulose, engineered specifically for advanced pharmaceutical applications. As a multifunctional excipient, HPMCAS is prized for its ability to significantly enhance the solubility and bioavailability of poorly soluble drugs, ensuring optimal drug absorption and therapeutic efficacy in complex formulations.
Designed for precision, HPMCAS serves as an indispensable material for enteric coating, sustained-release, and controlled-release preparations. Its unique pH-dependent solubility allows it to remain stable in the acidic environment of the stomach while dissolving rapidly in the neutral to alkaline environment of the small intestine, providing a sophisticated solution for targeted drug delivery and protection against moisture degradation.
Detailed Parameters
| Viscosity (mpa.s) | 20-5000 | Loss on Drying (%) | ≤5.0 |
|---|---|---|---|
| Residue on Ignition (%) | ≤0.2 | Arsenic (ppm) | ≤2.0 |
| Heavy Metals (ppm) | ≤10.0 | Acetyl Content (%) | 2.0-16.0 |
| Succinyl Content (%) | 4.0-28.0 | Methoxy Content (%) | 12.0-28.0 |
| 2-Hydroxypropoxy (%) | 4.0-23.0 | Pharmacopoeia Standard | CP 2020 (Vol 4) |
Key Advantages
Superior Barrier
Low water vapor permeability effectively blocks moisture penetration, preventing drug agglomeration and degradation.
Precise Release
Optimizes drug release rates based on pH levels, reducing dosing frequency and improving therapeutic outcomes.
High Solubility
Rapidly dissolves in intestinal juices (within 30 mins) while remaining stable in gastric juices for over 3.5 hours.
Dense Film Formation
Forms a smooth, transparent, and dense film upon solvent evaporation, ensuring a professional coating finish.
Enhanced Bioavailability
Acts as a solid dispersion carrier to increase the absorption efficiency of poorly soluble pharmaceutical active ingredients.
Eco-Friendly
Biodegradable polymer based on natural cellulose modification, aligning with modern environmental protection standards.
Product Gallery
Management Platforms
Raw Material Sourcing
Selection of premium wood pulp and cotton linters to ensure a high-purity cellulose base.
Alkalinization Control
Precise NaOH treatment to open the hydrogen bond network for efficient subsequent reactions.
Etherification Process
Controlled introduction of methoxy and hydroxypropoxy groups to form the HPMC intermediate.
Esterification Stage
Advanced reaction with acetic and succinic anhydrides to achieve final HPMCAS properties.
Purification Systems
Multi-stage neutralization and washing to remove all residual acids and impurities.
QC Final Testing
Rigorous verification of degree of substitution, viscosity, and solubility before packaging.
Investment Return Comparison
| Feature Comparison | HPMCAS (Our Product) | Traditional CAP |
|---|---|---|
| Storage Stability | Highly Stable / Low Hydrolysis | Prone to Hydrolysis |
| Intestinal Dissolution | Rapid & Complete | Slow Dissolution |
| Moisture Barrier | Excellent / Low Permeability | Moderate Permeability |
| pH Sensitivity | Highly Precise (pH > 5.0) | Less Consistent |
| Environmental Impact | Biodegradable Cellulose | Synthetic Residues |
Frequently Asked Questions
Q: What makes HPMCAS a superior enteric coating material compared to CAP?
HPMCAS offers greater storage stability, dissolves significantly faster in the intestines, and is less susceptible to hydrolysis under high temperature and humidity conditions compared to Cellulose Acetate Phthalate (CAP).
Q: How does HPMCAS improve the bioavailability of drugs?
It acts as a solid dispersion carrier, which increases the solubility of poorly soluble drugs, thereby enhancing their absorption efficiency within the gastrointestinal tract.
Q: In what pH conditions is HPMCAS soluble?
HPMCAS is insoluble in water and acidic solutions (such as stomach acid) but becomes easily soluble in aqueous solutions with a pH higher than 5.0, making it ideal for intestinal targeting.
Q: Can HPMCAS be used for food packaging?
Yes, due to its exceptionally low water vapor permeability, HPMCAS can be utilized to create high-barrier food packaging materials that protect products from moisture and extend shelf life.
Q: What are the available grades for HPMCAS?
We offer both micro powder types (AS-LF, AS-MF, AS-HF) and granular types (AS-LG, AS-MG, AS-HG) with varying acetyl and succinyl contents to meet different formulation needs.
Q: How should HPMCAS be stored to maintain quality?
It should be stored in a cool, dry, and ventilated environment. Ensure the product is waterproof and moisture-proof, and keep it away from high temperatures and direct sunlight.
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