Hydroxypropyl Methylcellulose Phthalate HPMCP China Suppliers and Factory
Hydroxypropyl Methylcellulose Phthalate (HPMCP) is a premium-grade enteric film coating material engineered for high-performance pharmaceutical applications. Primarily utilized as an enteric coating and sustained-release skeleton material for tablets and granules, HPMCP provides a sophisticated pH-dependent release mechanism, ensuring active ingredients are protected from gastric acidity and released precisely in the intestinal tract.
Characterized as a white or off-white, odorless, and tasteless powder, HPMCP exhibits exceptional solubility in organic solvents while remaining insoluble in water. This unique physicochemical profile makes it the ideal choice for formulations requiring controlled dissolution, improved bioavailability, and superior storage stability compared to traditional acrylic resins or cellulose acetate phthalate.
Detailed Parameters
| Viscosity (mpa.s) | HP55: 32-48 | HP55S: 136-204 | HP50: 44-46 | Moisture (wt%) | ≤ 5.0% |
|---|---|---|---|
| Ignition Residue | ≤ 0.2 wt% | Oxide Content | ≤ 0.07 wt% |
| Arsenic (ppm) | ≤ 2 ppm | Heavy Metals (ppm) | ≤ 10 ppm |
| Phthaloyl (wt%) | HP55: 21.0-35.0 | HP55S: 21.0-27.0 | Methoxy (wt%) | 18.0-24.0 wt% |
| True Specific Gravity | 1.65 - 1.82 | Softening Point | 200 - 210°C |
Key Advantages
Superior Film Strength
High plasticity and excellent film-forming properties reduce the need for plasticizers, enhancing tablet appearance and structural integrity.
Precise pH Release
Dissolution is strictly pH-dependent (HP50 > 5.0; HP55 > 5.5), ensuring targeted delivery and higher drug bioavailability.
Chemical Stability
Unlike CAP, HPMCP contains no acetate groups, eliminating the risk of acetic acid release and subsequent drug deterioration.
Versatile Solubility
Highly soluble in acetone, methanol, and ethanol blends, allowing for flexible coating solution preparation.
Extended Shelf Life
Exceptional storage stability ensures the product remains effective for 3-4 years under recommended conditions.
Pharmacopoeia Compliant
Fully compliant with the 2020 Chinese Pharmacopoeia (Part IV), meeting strict medical and regulatory standards.
Product Gallery
Management Platforms
Enteric Coating
Ideal for protecting sensitive drugs from stomach acid and preventing gastric irritation.
Sustained Release
Acts as a skeleton material for granules and tablets to control drug release rates.
Capsule Adhesives
Used in the production of ammonium salt polymer enteric capsules for tough, transparent films.
Taste Masking
Effective masking agent to cover unpleasant tastes of active pharmaceutical ingredients.
Microencapsulation
Serves as a high-performance matrix for microspheres and microcapsule delivery systems.
Oral Membranes
Applicable in the development of specialized oral membranes and solid dispersion systems.
Investment Return Comparison
| Feature | HPMCP (Our Product) | Acrylic Resins / CAP |
|---|---|---|
| Drug Stability | Excellent (No acetic acid) | Moderate (Risk of deterioration) |
| Bioavailability | High (Quick dissolution) | Moderate (Slower release) |
| Film Strength | Strong / Plastic | Brittle (Requires plasticizers) |
| pH Sensitivity | High Precision (5.0-5.5) | Variable / Broad |
| Storage Life | 3-4 Years Stable | Shorter / Conditional |
Frequently Asked Questions
Q: What is the primary difference between HP55 and HP55S?
HP55S has a higher molecular weight compared to HP55, which results in stronger film strength and enhanced resistance to artificial gastric juice.
Q: Which solvents are most effective for preparing HPMCP coating solutions?
HPMCP is highly soluble in Acetone/Water (9:1), Dichloromethane/Ethanol (1:1), and Acetone/Ethanol (1:1) mixtures.
Q: How does HPMCP compare to Cellulose Acetate Phthalate (CAP)?
HPMCP is superior as it lacks acetate groups, meaning it does not release acetic acid during storage, preventing drug deterioration common with CAP.
Q: At what pH values do HP50 and HP55 dissolve?
HP50 is soluble in buffer media with a pH value greater than 5.0, while HP55 is soluble when the pH exceeds 5.5.
Q: Is HPMCP suitable for taste masking in oral dosage forms?
Yes, its insolubility in water and acidic environments makes it an excellent taste masking agent for medications with unpleasant flavors.
Q: What are the recommended storage conditions for HPMCP?
It should be stored in a cool, dry, and ventilated place, protected from high temperatures and direct sunlight, with strict moisture-proofing.
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