HPMCP Hydroxypropyl Methylcellulose Phthalate Factory and Suppliers in China
Hydroxypropyl Methylcellulose Phthalate (HPMCP) is a premium enteric film-coating material engineered for superior performance in pharmaceutical applications. As a pH-dependent polymer, it serves as a critical component for enteric coatings, sustained-release skeleton materials for tablets and granules, and microcapsule matrices, ensuring that active ingredients are released precisely within the intestinal tract.
Characterized as a white or off-white, odorless, and tasteless powder, HPMCP exhibits excellent solubility in organic solvents while remaining insoluble in water. This unique physicochemical profile makes it an ideal choice for complex formulations requiring controlled dissolution, high bioavailability, and exceptional storage stability, outperforming traditional alternatives like cellulose acetate phthalate.
Detailed Parameters
| Viscosity (mpa.s) | HP55: 32-48 | HP55S: 136-204 | HP50: 44-46 | Moisture (wt%) | ≤ 5.0% |
|---|---|---|---|
| Ignition Residue | ≤ 0.2% | Oxide (wt%) | ≤ 0.07% |
| Heavy Metals | ≤ 10 ppm | Arsenic (ppm) | ≤ 2 ppm |
| Free Phthalic Acid | ≤ 1.0% | Phthaloyl (wt%) | HP55: 21.0-35.0% | HP55S: 21.0-27.0% |
| Methoxy (wt%) | 18.0-22.0% | Hydroxypropoxy (wt%) | 5.0-10.0% |
Key Advantages
Superior Gastric Resistance
HP55S offers higher molecular weight and stronger film strength, providing enhanced protection against human gastric juices.
High Bioavailability
Dissolution pH is lower than acrylic resins (pH 5.0-5.5), allowing drugs to dissolve faster and increase absorption rates.
Plasticity & Film Strength
Excellent film-forming properties often eliminate the need for plasticizers, improving overall tablet appearance.
Chemical Stability
Unlike CAP, HPMCP contains no acetate groups, preventing the release of acetic acid and protecting drug integrity.
Long-term Stability
Exceptional storage stability ensuring the product does not deteriorate for 3-4 years under proper conditions.
Versatile Application
Suitable for enteric capsules, taste masking, microspheres, oral membranes, and gradient drug release systems.
Product Gallery
Management Platforms
Pharmacopoeia Compliance
Fully compliant with the 2020 Chinese Pharmacopoeia (Part IV) standards for medical safety.
Solubility Control
Precision solubility in organic solvents like acetone and ethanol for optimized coating solutions.
pH-Triggered Release
Engineered thresholds (pH 5.0 for HP50, pH 5.5 for HP55) for precise intestinal drug delivery.
Concentration Mastery
Optimized coating concentrations from 4% to 10% depending on tablet or granule requirements.
Packaging Standards
Securely packaged in 10kg cardboard barrels with PE lining to ensure moisture-proof transport.
Thermal Stability
High softening point of 200-210°C ensuring stability during various manufacturing processes.
Investment Return Comparison
| Feature | HPMCP (Our Product) | Traditional CAP |
|---|---|---|
| Chemical Stability | No acetic acid release | Potential acetic acid release |
| Drug Integrity | High (Low deterioration) | Moderate (Potential deterioration) |
| Gastric Resistance | Excellent (Especially HP55S) | Standard |
| Bioavailability | High (Fast intestinal dissolution) | Moderate |
| Plasticizer Need | Low to None | Typically Required |
Frequently Asked Questions
Q: What is the primary difference between HP55 and HP55S?
HP55S has a higher molecular weight than HP55, which results in stronger film strength and superior resistance to artificial gastric juices, making it ideal for high-protection requirements.
Q: In which solvents is HPMCP soluble?
It is soluble in organic solvents such as acetone, methanol, dichloromethane, and various mixtures of these (e.g., acetone/water 9:1), but it is insoluble in water and anhydrous ethanol.
Q: How does HPMCP compare to acrylic resins regarding drug release?
HPMCP has a lower dissolution pH (5.0-5.5) compared to acrylic resins, allowing the drug to dissolve more quickly in the intestine, which generally leads to higher bioavailability.
Q: What are the typical concentrations for coating solutions?
For tablets, concentrations generally range from 5-10%; for granules, they range from 4-7%, depending on the specific grade (HP55, HP55S, or HP50) used.
Q: How should HPMCP be stored to maintain its quality?
It should be stored in a cool, dry, and ventilated place. It is essential to keep the product waterproof and moisture-proof, avoiding high temperatures and direct sunlight.
Q: Can HPMCP be used for taste masking?
Yes, HPMCP is highly effective as a taste masking agent due to its ability to form a protective film that prevents the drug from dissolving in the oral cavity.
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