LowSubstituted Hydroxypropyl Cellulose LHPC Factory and Suppliers in China
Low-Substituted Hydroxypropyl Cellulose (L-HPC) is a high-performance pharmaceutical auxiliary material specifically engineered for advanced tablet production. Synthesized from alkali cellulose through a precise propylene oxide etherification process, L-HPC presents as a white, odorless, and tasteless powder. While insoluble in water and most organic solvents, it possesses a unique ability to swell rapidly upon contact with water, providing critical functionality in drug delivery systems.
As a non-ionic compound, L-HPC remains stable across various pH levels of gastric and intestinal fluids, ensuring it does not react with common active pharmaceutical ingredients (APIs). Its sophisticated molecular structure, characterized by high porosity and a massive internal surface area, makes it a premier choice for manufacturers seeking to optimize tablet disintegration, enhance drug dissolution rates, and improve overall bioavailability.
Detailed Parameters
| Appearance | White or off-white powder, odorless and tasteless | Identification | Complies with Chinese Pharmacopoeia 2020 (Vol 4) |
|---|---|---|---|
| Hydroxypropoxyl Content | 5.0% - 16.0% | PH Value | 5.0 - 7.5 |
| Loss on Drying | ≤ 5.0% | Burning Residue | ≤ 1.0% |
| Chloride Content | ≤ 0.20% | Iron Salt | ≤ 0.010% |
| Arsenic Salts | ≤ 0.0002% | Heavy Metals | ≤ 10 ppm |
Key Advantages
Chemical Stability
Non-ionic nature ensures no reaction with drugs and stability across varied pH levels in the GI tract.
Rapid Disintegration
Superior swelling capacity compared to starch, accelerating tablet breakdown and drug release.
Enhanced Hardness
Rough molecular structure creates a mosaic effect with drugs, significantly increasing tablet bonding strength.
Improved Bioavailability
Finer dispersion after disintegration allows for a faster dissolution rate and better drug absorption.
Versatile Application
Functions effectively as both a disintegrant and a binder in wet granulation and dry granule processes.
Strict Quality Control
Rigorous testing of substitution levels and particle size to ensure batch-to-batch consistency.
Product Gallery
Management Platforms
Raw Material Sourcing
Selection of premium wood pulp and cotton linters for maximum cellulose purity.
Etherification Control
Precise regulation of propylene oxide reaction under strict temperature and pressure.
Neutralization Process
Efficient pH adjustment and multi-stage washing to remove all reaction by-products.
Advanced Drying
Utilizing spray or drum drying to ensure optimal moisture content and stability.
Particle Engineering
Sophisticated crushing and screening to achieve precise particle size distributions.
Quality Assurance
Full-spectrum testing including solubility and substitution determination for every batch.
Investment Return Comparison
| Model Variant | Hydroxypropoxy Content | Primary Application |
|---|---|---|
| LH-20 | 13.0% - 16.0% | High-efficiency disintegration |
| LH-21 | 10.0% - 12.9% | Balanced binding and breakdown |
| LH-22 | 7.0% - 9.9% | Specialized stability needs |
| Standard Starch | N/A | Basic disintegration (Lower speed) |
| Traditional Binder | N/A | Binding only (Poor disintegration) |
Frequently Asked Questions
Q: What is the primary function of L-HPC in tablet manufacturing?
L-HPC acts primarily as a disintegrant to accelerate the breakdown of tablets and as a binder to increase tablet hardness and stability.
Q: How does L-HPC compare to starch as a disintegrant?
L-HPC offers much stronger swelling capabilities and faster moisture absorption than starch, leading to quicker disintegration and improved drug dissolution.
Q: What is the recommended dosage for L-HPC in pharmaceutical use?
For use as a disintegrant, the general dosage is 2-5%. When utilized as a tablet adhesive in wet granulation, the dosage typically ranges from 2-20%.
Q: Does the pH of the gastrointestinal tract affect the performance of L-HPC?
No, L-HPC is a non-ionic compound, meaning its properties are not affected by the pH values of gastric or intestinal fluids.
Q: How should L-HPC be stored to maintain its quality?
L-HPC should be stored in sealed polyethylene-lined cardboard barrels and kept in a moisture-proof environment to prevent degradation.
Q: Can L-HPC be used in dry granulation?
Yes, L-HPC is versatile and can be added to dry granules or incorporated into starch slurries as a binder to improve hardness and disintegration.
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