LowSubstituted Hydroxypropyl Cellulose LHPC China Factory and Suppliers
Low-Substituted Hydroxypropyl Cellulose (L-HPC) is a premium pharmaceutical auxiliary material specifically engineered for advanced tablet production. Synthesized from alkali cellulose through a precise propylene oxide etherification process, this non-ionic compound serves as a high-performance disintegrant and binder. Its unique chemical structure ensures that it remains unaffected by the pH values of gastric and intestinal fluids, ensuring maximum stability and compatibility with a wide range of active pharmaceutical ingredients (APIs).
Characterized by its exceptional swelling capacity and high porosity, L-HPC significantly accelerates the disintegration of tablets and enhances the dissolution rate of drugs. Beyond its role as a disintegrant, its rough molecular structure creates a superior mosaic effect with drug particles, increasing bonding strength and improving overall tablet hardness and smoothness. Whether used in wet granulation or as a dry additive, L-HPC is the preferred choice for optimizing bioavailability and tablet integrity.
Detailed Parameters
| Appearance | White or off-white powder, odorless and tasteless | Identification | Complies with Chinese Pharmacopoeia 2020 (Vol 4) |
|---|---|---|---|
| Hydroxypropoxyl Content | 5.0% - 16.0% | pH Value | 5.0 - 7.5 |
| Loss on Drying | ≤ 5.0% | Burning Residue | ≤ 1.0% |
| Chloride | ≤ 0.20% | Iron Salt | ≤ 0.010% |
| Arsenic Salts | ≤ 0.0002% | Heavy Metal | ≤ 10 ppm |
Key Advantages
Chemical Inertness
Non-ionic nature ensures no reaction with common drugs and stability across various pH levels in the GI tract.
Rapid Disintegration
Fast moisture absorption and strong swelling capacity accelerate tablet breakdown and drug release.
Enhanced Hardness
Superior bonding effect improves the hardness and smoothness of tablets, even for difficult-to-form drugs.
Bioavailability Boost
Finer dispersion after disintegration increases the surface area for drug dissolution and absorption.
Versatile Application
Effective as a disintegrant, filler, or binder in wet granulation, dry granules, or starch slurries.
Strict Quality Control
Rigorous testing for substitution, solubility, and particle size ensures consistent pharmaceutical grade quality.
Product Gallery
Management Platforms
Raw Material Sourcing
Utilizing high-purity wood pulp and cotton linter refined to remove all potential impurities.
Etherification Control
Precision control of temperature and pressure during propylene oxide reaction for stable substitution.
Purification Process
Multi-stage neutralization and washing to ensure residue-free, neutral pH pharmaceutical powder.
Advanced Drying
Implementation of spray or drum drying to maintain the structural integrity of the cellulose chain.
Particle Engineering
Precision crushing and screening to achieve specific particle size distributions (e.g., LH-20, LH-21).
Quality Assurance
Comprehensive testing against Pharmacopoeia standards for purity, metal content, and performance.
Investment Return Comparison
| Product Model | Substitution Range | Primary Function |
|---|---|---|
| LH-20 | 13.0% - 16.0% | High-Efficiency Disintegration |
| LH-21 | 10.0% - 12.9% | Balanced Binding & Disintegration |
| LH-22 | 7.0% - 9.9% | Enhanced Bonding Strength |
| Standard Starch | N/A | Basic Disintegration (Lower Speed) |
| Traditional Binders | N/A | High Hardness but Slower Dissolution |
Frequently Asked Questions
Q: What is the primary difference between L-HPC and standard HPC?
L-HPC has a lower substitution degree of hydroxypropyl groups, making it insoluble in water but capable of rapid swelling, which is ideal for disintegrants, whereas standard HPC is often used for its solubility and viscosity.
Q: How does L-HPC improve the bioavailability of a drug?
By accelerating tablet disintegration and creating a finer dispersion of the drug particles, L-HPC increases the effective surface area for dissolution, leading to faster absorption in the body.
Q: What is the recommended dosage for L-HPC as a disintegrant?
Typically, a dosage of 2-5% is recommended. It can be added internally during wet granulation or externally, or a combination of both for optimized results.
Q: Can L-HPC be used as a binder in pharmaceutical manufacturing?
Yes, L-HPC possesses excellent bonding properties. When used as a tablet adhesive in wet granulation, the general dosage ranges from 2% to 20% to increase tablet hardness.
Q: Is L-HPC compatible with different pH environments?
As a non-ionic compound, L-HPC is highly stable and not affected by the pH values of gastric or intestinal fluids, ensuring consistent performance throughout the digestive process.
Q: How should L-HPC be stored to maintain its quality?
L-HPC should be stored in cardboard barrels lined with polyethylene sealed bags. It is critical to keep the product in a moisture-proof environment to prevent clumping and degradation.
Optimize Your Tablet Formulation with High-Purity L-HPC
Contact UsWrite your message here and send it to us
