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Hydroxypropyl methylcellulose (HPMC) and hydroxyethyl cellulose (HEC) are both cellulose derivatives widely used in various industries, including pharmaceuticals, food, cosmetics, and construction. Despite their similar origins and chemical structures, these polymers exhibit distinct properties that make them suitable for different applications. This article aims to compare HPMC and HEC, focusing on their chemical characteristics, functional attributes, and common uses.