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PVA’s solubility in water is primarily due to the presence of hydroxyl (–OH) groups in its molecular structure. These polar groups can form hydrogen bonds with water molecules, allowing PVA to interact with water effectively. This property makes PVA an excellent candidate for applications where water solubility is required.


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One of the notable attributes of HPMC is its sensitivity to pH changes. The solubility and viscosity of HPMC solutions can be affected by the pH level, which is particularly important in pharmaceutical formulations. Medications often require specific pH ranges to ensure optimal absorption in the gastrointestinal tract. For example, HPMC is frequently used as a binder in tablet formulations, where maintaining a stable pH can influence the dissolution and bioavailability of active ingredients.


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