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Hydroxypropyl Methyl Cellulose is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) and has been extensively studied for its safety in various applications. It is non-toxic, non-irritating, and does not possess any known toxic effects when used appropriately. However, like any substance, individual sensitivities may occur, and it is essential for manufacturers to adhere to safety guidelines and regulatory standards.