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Hydroxyethyl starch is a multifaceted compound with significant applications across various fields, notably in medicine and industry. Its ability to act as a volume expander makes it indispensable in critical medical situations, while its role in enhancing product quality in the industrial sector is equally noteworthy. However, the potential risks associated with its usage underscore the importance of careful consideration and monitoring in medical treatments. As research continues, a clearer understanding of HES’s benefits and limitations will likely shape its future applications and regulations.