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Hydroxypropyl methylcellulose (HPMC) has emerged as a versatile excipient in the pharmaceutical industry, particularly renowned for its role in the formulation of various drug delivery systems. One of the critical physical properties influencing the stability and efficacy of HPMC-based formulations is its glass transition temperature (Tg). The glass transition temperature is a pivotal phenomenon that characterizes the transition between the glassy and rubbery states of amorphous materials, such as polymers.