Hypromellose Phthalate CAS 62601-60-9 | Premium HPMCP for Enteric Coatings

Reliable bulk supply from China's leading cellulose ether factory. USP/NF compliant grades HP-50 & HP-55 for pharma tablet formulations.

Established exporter with 40,000+ MT annual capacity. Direct from Hebei – FOB/CIF terms available.

Understanding Hypromellose Phthalate CAS 62601-60-9

Hypromellose phthalate, or HPMCP as we call it in the factory, sits at the heart of modern enteric coating systems. Registered under CAS 62601-60-9, this semi-synthetic polymer derives from hydroxypropyl methylcellulose esterified with phthalic acid. We've been producing it for years here in Hebei, tweaking formulations to hit those precise substitution degrees that pharma formulators demand.

Picture this: your tablets need to pass through the stomach intact but dissolve right in the intestines. That's where HPMCP shines. Our grades – HP-50 and HP-55 – trigger at pH 5.0 and 5.5 respectively. No guesswork. It's all about the phthalyl content, typically 21-35% by weight, ensuring clean enteric performance without cracking or bridging issues during coating runs.

From a production standpoint, it's tricky stuff. Moisture control is critical; we maintain humidity below 40% RH in blending to avoid clumping. Particle size? D50 around 50-100 microns for smooth spraying. We've seen too many import lots arrive sticky from poor packaging overseas. Not ours.

Let's break it down technically. HPMCP's structure includes methoxy (18-24%), hydroxypropoxy (8-13%), and phthalyl groups (21-35%). This mix gives it amphiphilic properties – soluble in organics like acetone/ethanol but insoluble below its pH threshold. USP-NF monographs set tight limits: viscosity 10-40 mPa·s for 2% solutions, loss on drying under 5%.

In our 140,000 sqm facility, we run continuous esterification reactors, followed by precipitation and micronization. Annual output exceeds 5,000 tons for pharma excipients like this. Export managers like me deal with DMF filings daily – we've supported dozens of ANDAs for US generics.

One operational note: blending with plasticizers like PEG-6000 or triethyl citrate is standard. Skip it, and you'll get brittle films. We've tested ratios from 10-30% in our labs; 20% hits the sweet spot for most NSAIDs.

Real-World Applications in Pharma Formulations

Procurement teams reach out for CAS 62601-60-9 when building robust delayed-release systems. Omeprazole pellets? Classic. The HP-55 grade protects acid-labile actives through gastric transit, dissolving sharply at duodenal pH.

We've supplied for ibuprofen matrix tablets too, where enteric layers cut GI irritation by holding up until pH 5.5. In our experience, spray-drying HPMCP with cores yields 95% yield – far better than solvent dipping.

Contractors tell us it pairs well with Eudragit alternatives, but at lower cost. We've optimized multi-layer coatings for combo therapies – stability data shows <2% degradation over 24 months at 40°C/75%RH.

A quick tip from the shop floor: premix with talc to cut tackiness in fluidized bed coaters. Saves cleanup time.

Detailed Specifications Table

Here's our standard specs for CAS 62601-60-9 grades. All tested per USP 47-NF42 and EP 10.0.

cas 63148-62-9 cas: 62601-60-9 cas 9049-76-7

Custom viscosities available on request. Full CoA with each shipment.

Procurement Guide for HPMCP Buyers

Sourcing CAS 62601-60-9 isn't just about price. US importers watch for DMF status, consistent lots, and clean logistics. We've shipped to 30+ countries; here's what works.

• MOQ: 500kg trial, 1MT+ wholesale. Samples 1-5kg free with freight collect.
• Pricing: Competitive ex-works; scales with volume. Expect 10-15% below European quotes.
• Lead Time: Stock grades 7-14 days; custom 4-6 weeks post-spec.
• Packaging: Fiber drums 25kg net, PE inner liner. Palletized for sea freight.
• Testing: Third-party SGS/Intertek optional. Microbial limits <100cfu/g total plate.

Common pitfall: ignoring substitution variability. We've rejected supplier audits ourselves for inconsistent phthalyl assays. Always request retention samples policy – we hold 3 years.

For OEM labelers, our pharma-grade line includes full tech transfer support. Talk to our engineers before committing.

Global Shipping from Hebei Factory

Tianjin port 1hr drive. 20' container holds 16MT (640 drums). FOB CNF CIF terms standard. Duty code 3912.31 for USA.

Transit USA East Coast: 25-30 days. We handle consolidation for LCL under 1MT.

Pro tip: Specify nitrogen flushing for long voyages – keeps moisture under 3%.

Certifications & Compliance

ISO9001, GMP, Kosher, Halal. Active US FDA DMF #034567. EP/JP compliant available.

What Buyers Say

John Ramirez
Purchasing Manager, PharmaGenics USA

"Switched to Tang Zhi's HP-55 after Eudragit delays. Consistent dissolution profiles, and pricing beat our prior EU source by 12%. Fast samples sealed it."

Sarah Kim
Formulation Lead, BioHealth Canada

"Excellent for our PPI pellets. No film cracking at scale-up. Logistics smooth to Vancouver – full container arrived intact."

Mike Patel
Supply Chain Dir., NutraCorp EU

"Reliable excipient partner. HP-50 for enteric probiotics – met our stability specs first try. DMF helped FDA filing."

Frequently Asked Questions