Ethylcellulose Aqueous Dispersion

Ethylcellulose Aqueous Dispersion(EAD)

Ethylcellulose is a nonionic, water-insoluble cellulose ether that is often used in applications where water resistance or controlled release is required. However, it is difficult to disperse it directly in water due to its hydrophobicity. To overcome this challenge and take advantage of the excellent properties of ethylcellulose, aqueous ethylcellulose dispersions were developed.

EAD ( Ethylcellulose aqueous dispersion)

It consists of ethyl cellulose, plasticizer, emulsifier and other solid ingredients and water.

Conforms to the standards of the Chinese Pharmacopoeia 2020 edition (Volume 4)

┃ Good handling performance.

Although the solid content is high, the viscosity is still low, which can shorten the coating time compared with other water-soluble coating agents.

Low adhesion, the coated material is not easy to stick during coating.

┃Dissolution characteristics not affected by pH value.

Not affected by pH differences caused by differences in the human body or the location of the digestive tract, it can control the dissolution over time.

When used in combination with other water-soluble polymers, dissolution-controlled preparations with higher degrees of freedom can be designed.

┃ When used for tablets with engraving, due to its low viscosity, it will not produce
unclear printing.

Compared with previous water-soluble coating agents, the moisture permeability
of the coating film is low, which can give the preparation excellent moisture-proof
performance.

┃ Compared with similar foreign products, TZ-EAD contains plasticizers and has no
ammonia smell, so it does not need to add plasticizers during coating.

┃ Compared with organic solvents, it not only saves costs, but also avoids the
occurrence of flammable and explosive hazards.

┃ TZ-EAD is suitable for both water-soluble drugs and poorly soluble drugs.

TZ-EAD aqueous coating liquid is a commonly used sustained-release and controlled-release coating material, which is widely used in the preparation of coated sustained-release and controlled-release tablets, pellets, and granules. It is used to prepare skeleton-type sustained-release tablets. Different ratios of TZ-EAD/HPMC can form coating films with different solubility to adjust the drug release rate.

• 
  01

  Tablets - Coating

  Due to its good film-forming properties, aqueous ethylcellulose dispersions are widely used in film coatings of tablets, granules and other solid dosage forms. This coating not only improves the appearance of the drug, but also protects the drug from environmental factors (such as humidity, oxygen), while regulating the solubility and release rate of the drug.

• 
  02

  Micropellets-Sustained Release

  As a hydrophobic polymer, ethylcellulose can effectively control the release rate of drugs from micropellets. By adjusting the concentration of ethylcellulose aqueous dispersion and coating thickness, precise control of different drug release patterns can be achieved to meet specific therapeutic needs.

1. Dissolve 2kg of ethyl cellulose (N50), 6L of dichloromethane, and 200g of hexadecanol in a 35℃ water bath for 12h; dissolve 96g of sodium dodecyl sulfate in 10kg of water for later use;

2. Slowly add the dissolved sodium dodecyl sulfate solution to the ethyl cellulose solution in a 35℃ water bath, and stir continuously for emulsification. After the addition is completed, continue stirring in a 35 water bath for 2h, and cool down with circulating water for 1h;

3. Homogenize with a high-pressure homogenizer, connect the outlet pipe of the homogenizer to the condenser, turn on the homogenizer, control the pressure at 20MPa for the first homogenization; control the pressure at 30MPa for the second homogenization: control the pressure at 40MPa for the third homogenization;

4. Transfer the homogenized emulsion to a three-necked flask, connect the distiller under a 45℃ water bath, and distill at normal pressure until all the dichloromethane is distilled, ensuring that the solid content of the emulsion is about 10%.

Packaging material: plastic container;

Net weight: 3kg, 15kg, 50kg

Precautions！

Ethylcellulose aqueous dispersions should be stored in a cool, dry place between 5°C and 30°C, protected from freezing, light and moisture, tightly sealed and away from incompatible materials, following the manufacturer's specific guidelines.