CCMC-Na

Cross-linked sodium carboxymethyl cellulose(CCMC-Na)

Cross-linked sodium carboxymethyl cellulose is a chemically modified cellulose derivative, mainly used in the pharmaceutical industry as a super disintegrant for tablets and capsules. By introducing a cross-linked structure, the product can quickly absorb water, swell and disintegrate in water, but will not dissolve, thereby accelerating the dissolution rate of the drug and improving its efficacy.

CCMC-Na ( Cross-linked sodium carboxymethyl cellulose)

It is usually present in the form of white or off-white fine powder or granules. Due to its specific particle size distribution and surface characteristics, cross-linked sodium carboxymethyl cellulose exhibits good flow properties, which facilitates mixing and filling operations in the pharmaceutical process.

Conforms to the standards of the Chinese Pharmacopoeia 2020 edition (Volume 4)

Highly efficient disintegration performance: This is one of its most important characteristics. When used as a disintegrant in tablets or capsules, it can quickly absorb water and swell, but will not dissolve, thereby accelerating the disintegration rate of the preparation and promoting the dissolution and absorption of the drug.

Good water absorption: Cross-linked carboxymethyl cellulose sodium has a strong water absorption capacity and can absorb a large amount of water in a short time, which helps to improve its disintegration efficiency.

Chemical stability: It has good chemical stability, can remain stable in a wide range of pH values, is not prone to degradation or deterioration, and is suitable for use in a variety of drug formulations.

Good biocompatibility: As a commonly used pharmaceutical excipient, cross-linked carboxymethyl cellulose sodium is non-toxic and non-irritating to the human body and has good biocompatibility.

Does not affect drug activity: It has good compatibility with a variety of active ingredients and other excipients, does not affect the active ingredients of the drug, and ensures the safety and effectiveness of the drug.

Improve the physical properties of the preparation: It can enhance the hardness of the tablet, reduce brittleness, and improve the appearance and smoothness of the tablet.

In the wet granulation process, cross-linked sodium carboxymethyl cellulose can be added in the wetting stage or the drying stage (inside the granules and outside the granules), but the effect of adding outside is better than that of adding inside. The swelling of cross-linked sodium methyl cellulose in water is greater than that of common disintegrants such as low-substituted sodium carboxymethyl cellulose and hydrated microcrystalline cellulose. Whether this product is added inside or outside, the brittleness of the tablet is not affected, and the disintegration time and release effect of the tablets made with it will not change over time. When used as a disintegrant, the dosage can reach 5.0% (W/W), but the dosage is usually 2.0% (W/W) in the direct tableting process and 3.0% (W/W) in the wet granulation process.

Disintegrators - tablets, capsules, granules

It is used as a disintegrant in tablets, capsules and granules. The common dosage in tablets is 0.5%~5.0%. It is characterized by good compressibility and strong disintegration. In the tablet production process, this product is suitable for direct tableting and wet granulation tableting.

Crosslinked sodium carboxymethyl cellulose is generally considered non-toxic and non-irritating, but may be slightly irritating to the eyes. It has a laxative effect when taken orally in large quantities, but the amount used in solid preparations is not likely to cause this problem.

Crosslinked sodium carboxymethyl cellulose is incompatible with strong acids, soluble salts of iron or other metals (such as aluminum, mercury, and zinc).

Cross-linked sodium carboxymethyl cellulose is an important chemical substance with wide applications in many fields such as medicine and food. The following will introduce its preparation method in detail.

1. Prepare materials and equipment

First, you need to prepare raw materials such as sodium carboxymethyl cellulose and cross-linking agent, as well as equipment such as reactors, stirrers, and thermometers. Make sure all materials and equipment are clean and meet production standards.

2. Dissolution and mixing

Add sodium carboxymethyl cellulose to an appropriate amount of water and stir to fully dissolve it. Then, slowly add the cross-linking agent while stirring to ensure that the two are fully mixed. This process requires controlling the temperature and stirring speed to ensure that the reaction proceeds evenly.

3. Cross-linking reaction

Under appropriate temperature and pH conditions, sodium carboxymethyl cellulose and the cross-linking agent undergo cross-linking reaction. During the reaction, the temperature and pH value need to be continuously monitored to ensure that the reaction conditions are stable. The time of the cross-linking reaction depends on the specific reaction conditions and the desired degree of cross-linking.

4. Post-treatment and purification

After the cross-linking reaction is completed, the product needs to be post-treated and purified. This usually includes steps such as filtering, washing, and drying to remove unreacted raw materials and impurities. The final cross-linked sodium carboxymethyl cellulose should be white or off-white powder.

5. Quality Control and Testing

After preparation, cross-linked sodium carboxymethyl cellulose needs to be quality controlled and tested. This includes checking its appearance, solubility, cross-linking degree and other indicators to ensure that it meets relevant standards and requirements.

This product is highly hygroscopic and should be placed in a sealed container in a cool and dry place.

Paper-plastic composite woven bag, lined with double-layer polyethylene bag.

Net weight: 25kg/bag.